Мікро-РНК: властивості та роль у розвитку та прогресуванні неалкогольної жирової хвороби печінки
DOI:
https://doi.org/10.30978/MG-2018-6-72Ключові слова:
неалкогольна жирова хвороба печінки, мікро-РНК, діагностичні біомаркери, стеатоз, фіброзАнотація
Мікро-РНК — невеликі некодуючі РНК, які регулюють різноманітні фізіологічні та патологічні процеси шляхом модуляції експресії генів на посттранскрипційному рівні. Доведено роль мікро-РНК у розвитку та прогресуванні захворювань печінки, зокрема неалкогольної жирової хвороби печінки. Обговорюється можливість використання мікро-РНК як діагностичних маркерів. З великої кількості мікро-РНК найбільшу участь у розвитку неалкогольної жирової хвороби печінки беруть miR-34a, miR-122 та miR-155.
Посилання
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